مرکز تحقیقات نورولوژی بالینی | Mohammad Saied Salehi
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Dr. Mohammad Saied Salehi
Assistant Professor at Clinical Neurology Research Center
Shiraz University of Medical Sciences
saied.salehi@gmail.com; saied_salehi@sums.ac.ir

INTRODUCTION

 Currently, I am Assistant Professor at the Clinical Neurology Research Center (CNRC), Shiraz University of Medical Sciences, Iran. I was awardee of International Brain Research Organization (IBRO) Research Fellowship 2019 and spent one-year sabbatical at the University of Regensburg, Germany, under the supervision of Prof Dr Inga D Neumann. Also, I had a post-doctoral appointment at the CNRC that was supported by Iran National Science Foundation and Iran National Elites Foundation under the supervision of Prof Dr Afshin Borhani-Haghighi.
Seeking new alternatives to treat ischemic stroke in order to ameliorate neurological function and reduce mortality is of paramount necessity. Nestin-expressing hair follicle stem cells (HFSCs, also known as epidermal neural crest stem cells [EPI-NCSCs] and hair follicle-associated-pluripotent [HAP] stem cells) are remnants of the embryonic neural crest, residing in the bulge of adult hair follicle. These cells can be differentiated into neurons as well as glial cells and also express variety of neurotrophic factors. Our group have been studying HFSCs and their role in the treatment of ischemic stroke.
 
INTERNATIONAL HONORS and AWARDS
  1. Received International Brain Research Organization (IBRO) Research Fellowship Award 2019 (35000 Euro) to spend one-year sabbatical at the Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg- Germany, under the supervision of Prof. Dr. Inga D. Neumann.
  2. Received International Brain Research Organization (IBRO) travel grant 2017 for participation in the FENS Regional Meeting, 20-23 September 2017, Pécs, Hungary.
  3. Selected as a recipient of Federation of European Neuroscience Societies (FENS) travel grant 2017 for participation in the FENS Regional Meeting, 20-23 September 2017, Pécs, Hungary.
  4. Selected for participation in the 2nd IBRO/APRC Chandigarh neuroscience school, 14-22 December 2016, Chandigarh, India.
  5. Received Federation of European Neuroscience Societies stipend award for participation in FENS-SfN summer school: Cellular mechanisms and networks in addiction, 29 May - 4 June 2016, Bertinoro, Italy.

NATIONAL HONORS and AWARDS

  1. Received Iran’s National Elites Foundation grant 2021 (Dr. Kazem Ashtiani Award) for junior scientists.
  2. Received Iran National Science Foundation (INSF) grant 2018 for postdoctoral researchers.
  3.  Received Iran’s National Elites Foundation grant 2018 (Shahid Chamran Award) to be a postdoctoral fellow at the Shiraz University of Medical Sciences.
  4. Achieved military service facilities of Iran’s National Elites Foundation in a form of research project at the Aja University of Medical Sciences, 2015, Tehran, Iran.
  5. Selected for participation in the 4th IBRO/APRC Tehran neuroscience school, 17-28 October 2014, Tehran, Iran.

 

PUBLICATIONS

      Papers in Refereed Journals

 

  1. Ghobadi, M., Akbari, S., Bayat, M., Shid Moosavi, S.M., Salehi, M.S., Pandamooz, S., Azarpira, N., Afshari, A., Hooshmandi, E., Haghani, M., Gens PSD‐95 and GSK‐3β expression improved by hair follicular stem cells‐conditioned medium enhances synaptic transmission and cognitive abilities in the rat model of vascular dementia. Brain and Behavior 2024, 14: e3351. Download

  2. Akbari, S., Haghani, M., Ghobadi, M., Hooshmandi, E., Borhani-Haghighi, A., Salehi, M.S., Pandamooz, S., Azarpira, N., Afshari, A., Zabihi, S., Nemati, M., Bayat, M., Combination therapy with platelet-rich plasma and epidermal neural crest stem cells increases treatment efficacy in vascular dementia. Stem Cells International 2023, 3784843. Download

  3. Tavakkoli, Z., Salehi, M.S., Jameie, S., Rahmi, M., Koohpeyma, F., Dianatpour, M., Miyan, J.A., Pandamooz, S., Simple methods for cerebrospinal fluid collection in fetal, neonatal, and adult rat. Journal of Neuroscience Methods 2023, 399: 109971. Download

  4. Hooshmandi, E., Akbari, S., Pandamooz, S., Ghobadi, M., Ghasemi, R., Maghsoudi, N., Rai, S.N., Borhani‑Haghighi, A., Salehi, M.S., Azarpira, N., YousefiNejad, A., Haghani, M., Bayat, M., Combined use of hair follicle stem cells and CEPO (carbamylated erythropoietin)-Fc in a rat model of chronic cerebral hypoperfusion: A behavioral, electrophysiological, and molecular study. Behavioural Brain Research 2023, 454: 114655. Download

  5. Pandamooz, S., Salehi, M.S., Jurek, B., Meinung, C-P., Azarpira, N., Dianatpour, M., Neumann, I.D., Oxytocin receptor expression in hair follicle stem cells: a promising model for biological and therapeutic discovery in neuropsychiatric disorders. Stem Cell Reviews and Reports 2023, 19: 2510–2524. Download

  6. Jashire Nezhad, N., Safari, A., Namavar, M.R., Nami, M., Karimi-Haghighi, S., Pandamooz, S., Dianatpour, M., Azarpira, N., Khodabandeh, Z., Zare, S., Hooshmandi, E., Bayat, M., Owjfard, M., Zafarmand, S.S., Fadakar, N., Rahimi Jaberi, A., Salehi, M.S., Borhani‑Haghighi, A., Short-term beneficial effects of human dental pulp stem cells and their secretome in a rat model of mild ischemic stroke. Journal of Stroke and Cerebrovascular Diseases 2023, 32: 107202. Download

  7. Estakhr, M., et al., The hospitalization rate and clinical characteristics of mucormycosis prior and during COVID-19 pandemic: A single-center study. Journal of Infection in Developing Countries 2023, 17: 791-799. Download

  8. Karimi-Haghighi, S., Pandamooz, S., Jurek, B., Fattahi, S., Safari, A., Azarpira, N., Dianatpour, M., Hooshmandi, E., Bayat, M., Owjfard, M., Zafarmand, S.S., Mostaghel, M., Mousavi, S.M., Jashire Nezhad, N., Eraghi, V., Fadakar, N., Rahimi Jaberi, A., Garcia-Esperon, C., Spratt, N., Levi, C., Salehi, M.S., Borhani‑Haghighi, A., From hair to the brain: The short-term therapeutic potential of human hair follicle-derived stem cells and their conditioned medium in a rat model of stroke. Molecular Neurobiology 2023, 60: 2587-2601. Download
  9. Pandamooz, S., Jurek, B., Dianatpour, M., Haerteis, S., Limm, K., Oefner, P.J., Dargahi, L., Borhani‑Haghighi, A., Miyan, J.A., Salehi, M.S., The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells. Cell Proliferation 2023, 56: e13397. Download

  10. Owjfard, M., Karimi, F., Mallahzadeh, A., Nabavizadeh, S.A., Namavar, M.R., Iravani Saadi, M., Hooshmandi, E., Salehi, M.S., Zafarmand, S.S., Bayat, M., Karimlou, S., Borhani-Haghighi, A., Mechanism of action and therapeutic potential of dimethyl fumarate in ischemic stroke. Journal of Neuroscience Research 2023, 101: 1433-1446. Download

  11. Bayat, M., Tabrizi, R., Salehi, M.S., Karimi, N., Rahimi, M., Hooshmandi, E., Razavi moosavi, N., Fadakar, N., Borhani-Haghighi, A., Association of long non-coding RNA Malat1 with serum levels of interleukin-1 beta and vitamin D in patients with ischemic stroke. Galen Medical Journal 2023, 12: e2457. Download
  12. Keshavarz, S., Nemati, M., Salehi, M.S., Naseh, M., The impact of anesthetic drugs on hemodynamic parameters and neurological outcomes following temporal middle cerebral artery occlusion in rats. NeuroReport 2023, 34: 199-204. Download
  13. Jurek, B., Denk, L., Schafer, N., Salehi, M.S., Pandamooz, S., Haerteis, S., Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping. Frontiers in Cellular Neuroscience 2022, 16:1000538. Download
  14. Pandamooz, S., Salehi, M.S., Dianatpour, M., Miyan, J.A., Could embryonic cerebrospinal fluid direct the fate of hair follicle stem cells towards dopaminergic neurons to treat Parkinson’s disease? Stem Cell Reviews and Reports 2022, 18: 3115-3117. Download
  15. Mousavi, S.M., Karimi-Haghighi, S., Chavoshinezhad, S., Pandamooz, S., Belem-Filho, I.J.A., Keshavarz, S., Bayat, M., Hooshmandi, E., Rahimi Jaberi, A., Salehi, M.S., Borhani-Haghighi, A., The impacts of anesthetic regimens on the middle cerebral artery occlusion outcomes in male rats. NeuroReport 2022, 33:561-568. Download
  16. Salehi, M.S., Pandamooz, S., Tamadon, A., Jafarzadeh Shirazi, M.R., Borhani‑Haghighi, A., Reproductive complications after stroke: Long-lasting impairment of gonadotropin-releasing hormone neuronal network? Biology of Reproduction 2022, 107: 368-370. Download
  17. Borhani-Haghighi, A., et al., Early and mid-term outcomes of carotid angioplasty and stent placement in 579 patients. Journal of Neuroimaging 2022. https://doi.org/10.1111/jon.13036. Download
  18. Mousavi, S.M., Akbarpour, B., Karimi-Haghighi, S., Pandamooz, S., Belem-Filho, I.J.A., Masis-Calvo, M., Salimi, H., Lashanizadegan, R., Pouramini, A., Owjfard, M., Hooshmandi, E., Bayat, M., Zafarmand, S.S., Dianatpour, M., Salehi, M.S., Borhani-Haghighi, A., Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke. BMC Neuroscience 2022, 23:47. Download
  19. Salehi, M.S., Jurek, B., Karimi-Haghighi, S., Jashire Nezhad, N., Mousavi, S.M., Hooshmandi, E., Safari, A., Dianatpour, M., Haerteis, S., Miyan, J.A., Pandamooz, S., Borhani-Haghighi, A., Intranasal application of stem cells and their derivatives as a new hope in the treatment of cerebral hypoxia/ischemia: a review. Reviews in the Neurosciences 2022. 33: 583-606. Download
  20. Pandamooz, S., Jurek, B., Meinung, C.P., Baharvand, Z., Sahebi Shahem-abadi, A., Haerteis, S., Miyan, J.A., Downing, J., Dianatpour, M., Borhani-Haghighi, A., Salehi, M.S., Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments. Annual Review of Pharmacology and Toxicology 2022, 62: 25-53. Download
  21. Salehi, M.S., Safari, A., Pandamooz, S., Jurek, B., Hooshmandi, E., Owjfard, M., Bayat, M., Zafarmand, S.S., Miyan, J.A., Borhani‑Haghighi, A., The beneficial potential of genetically modified stem cells in the treatment of stroke: a review. Stem Cell Reviews and Reports 2022, 18: 412-440. Download
  22. Karimi-Haghighi, S., Chavoshinezhad, S., Safari, A., Razeghian-Jahromi, I., Jamhiri, I., Khodabandeh, Z., Khajeh, S., Zare, S., Borhani-Haghighi, A., Dianatpour, M., Pandamooz, S., Salehi, M.S., Preconditioning with secretome of neural crest-derived stem cells enhanced neurotrophic expression in mesenchymal stem cells. Neuroscience Letters 2022, 773: 136511. Download
  23. Akbari, S., Hooshmandi, E., Bayat, M., Borhani-Haghighi, A., Salehi, M.S., Pandamooz, S., Yousefi Nejad, A., Haghani, M., The neuroprotective properties and therapeutic potential of epidermal neural crest stem cells transplantation in a rat model of vascular dementia. Brain Research 2022, 1776: 147750. Download
  24. Vasaghi Gharamaleki, M., et al., The hospitalization rate of cerebral venous sinus thrombosis before and during COVID-19 pandemic era: a single-center retrospective cohort study. Journal of Stroke and Cerebrovascular Diseases 2022, 31: 106468. Download
  25. Rostamihosseinkhani, M., et al., True mycotic aneurysms: a report of three patients with internal carotid artery aneurysm and mucormycosis and literature review. Shiraz E Medical Journal 2022, 23: e127071. Download
  26. Zafarmand, S.S., Karimi-Haghighi, S., Salehi, M.S., Hooshmandi, E., Owjfard, M., Bayat, M., Karimlou, S., Pandamooz, S., Dianatpour, M., Borhani-Haghighi, A., Aspirin impacts on stem cells: Implications for therapeutic targets. Tissue and Cell 2022, 74: 101707. Download
  27. Zafarmand, S.S., Salehi, M.S., Mokhtari, M.J., Safari, A., Pandamooz, S., Dianatpour, M., Borhani-Haghighi, A., Acetylsalicylic acid enhanced neurotrophic profile of epidermal neural crest stem cells: a possible approach for the combination therapy. Physiology and Pharmacology 2022, 26: 200-212. Download
  28. Salehi, M.S., Neumann, I.D., Jurek, B., Pandamooz, S., Co-stimulation of oxytocin and arginine-vasopressin receptors affect hypothalamic neurospheroid size. International Journal of Molecular Sciences 2021, 22: 8646. Download
  29. Pandamooz, S., Jurek, B., Salehi, M.S., Mostaghel, M., Miyan, J.A., Dianatpour, M., Borhani-Haghighi, A., The implementation of preconditioned epidermal neural crest stem cells to combat ischemic stroke. Brain Sciences 2021, 11: 653. Download
  30. Chavoshinezhad, S., Zibaii, M.S., Seyed Nazari, M.H., Ronaghi, A., Asgari Taei, A., Ahmad Ghorbani, A., Pandamooz, S., Salehi, M.S., Valian, N., Motamedi, F., Haghparast, A., Dargahi, A., Optogenetic stimulation of entorhinal cortex reveals the implication of insulin signaling in adult rat's hippocampal neurogenesis. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2021, 111: 110344. Download
  31. Ostovan, V.R., Foroughi, R., Rostami, M., Almasi‑Dooghaee, M., Manouchehr Esmaili, M., Bidaki, A.A., Behzadi, Z., Farzadfard, F., Marbooti, H., Rahimi‑Jaberi, A., Poursadeghfard, M., Fadakar, N., Bayat, M., Owjfard, M., Salehi, M.S., Zafarmand, S.S., Mardi, F., Safari, S., Shima Shahjouei, S., Mowla, A., Azarpazhooh, M.R., Zand, R., Hooshmandi, E., Borhani‑Haghighi, A., Cerebral venous sinus thrombosis associated with COVID-19: a case series and literature review. Journal of Neurology 2021, 268: 3549-3560. Download
  32. Salehi, M.S., Pandamooz, S., Jurek, B., Epidermal neural crest stem cells as a perspective for COVID-19 treatment. Stem Cell Reviews and Reports 2021, 17: 291-292. Download
  33. Salehi, M.S., Pandamooz, S., Safari, A., Jurek, B., Tamadon, A., Namavar, M.R., Dianatpour, M., Dargahi, L., Azarpira, N., Fattahi, S., Shid Moosavi, S.M., Keshavarz, S., Khodabandeh, Z., Zare, S., Nazari, S., Heidari, M., Izadi, S., Poursadeghfard, M., Borhani-Haghighi, A., Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke. CNS Neuroscience & Therapeutics 2020, 26: 670-681. Download
  34. Pandamooz, S., Jafari, A., Salehi, M.S., Jurek, B., Ahmadiani, A., Safari, A., Hassanajili, S., Borhani‐Haghighi, A., Dianatpour, M., Niknejad, H., Azarpira, N., Dargahi, L., Substrate stiffness affects the morphology and gene expression of epidermal neural crest stem cells in a short term culture. Biotechnology & Bioengineering 2020, 117: 305-317. Download
  35. Salehi, M.S., Khazali, H., Mahmoudi, F., Janahmadi, M., The effects of supraphysiological levels of testosterone on neural networks upstream of gonadotropin-releasing hormone neurons. Iranian Journal of Basic Medical Sciences 2019, 22: 1065-1072. Download
  36. Chavoshinezahd, S., Mohseni Kouchesfahani, H., Salehi, M.S., Pandamooz, S., Ahmadiani, A., Dargahi, L., Intranasal interferon beta improves memory and modulates inflammatory responses in a mutant APP-overexpressing rat model of Alzheimer’s disease. Brain Research Bulletin 2019, 297-306. Download
  37. Pandamooz, S., Salehi, M.S., Safari, A., Azarpira, N., Hervari, M., Ahmadiani, A., Dargahi, L., Enhancing the expression of neurotrophic factors in epidermal neural crest stem cells by valproic acid: A potential candidate for combinatorial treatment. Neuroscience Letters 2019, 704: 8-14. Download
  38. Salehi, M.S., Borhani-Haghighi, A., Pandamooz, S., Safari, A., Dargahi, L., Dianatpour, M., Tanideh, N., Dimethyl fumarate up-regulates expression of major neurotrophic factors in the epidermal neural crest stem cells. Tissue and Cell 2019, 56: 114-120. Download
  39. Pandamooz, S., Salehi, M.S., Zibaii, M.I., Safari, A., Nabiuni, M., Ahmadiani, A., Dargahi, L., Modeling traumatic injury in organotypic spinal cord slice culture obtained from adult rat. Tissue and Cell 2019, 56: 90-97. Download
  40. Pandamooz, S., Salehi, M.S., Zibaii, M.I., Ahmadiani, A., Nabiuni, M., Dargahi, L., Epidermal neural crest stem cell-derived glia enhance neurotrophic elements in an ex vivo model of spinal cord injury. Journal of Cellular Biochemistry 2018, 119(4): 3486-3496. Download
  41. Wang, H., Khoradmehr, A., Jalali, M., Salehi, MS., Tsutsui, K., Jafarzadeh Shirazi, MR., Tamadon, A., The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction. Iranian Journal of Basic Medical Sciences 2018, 21: 1210-1220. Download
  42. Salehi, M.S., Pandamooz, S., Khazali, H., Oxytocin intranasal administration as a new hope for hypogonadotropic hypogonadism patients. Medical Hypotheses 2017, 109: 88-89. Download
  43. Salehi, M.S., Khazali, H., Mahmoudi, F., Janahmadi, M., Oxytocin intranasal administration affects neural networks upstream of GNRH neurons. Journal of Molecular Neuroscience 2017, 62: 356-362. Download
  44. Salehi, M.S., Namavar, M.R., Tamadon, A., Bahmani, R., Jafarzadeh Shirazi, M.R., Khazali, H., Dargahi, L., Pandamooz, S., Mohammad-Rezazadeh, F., Rashidi, F.S., The effects of acoustic white noise on the rat central auditory system during the fetal and critical neonatal periods: a stereological study. Noise & Health 2017, 19(86): 24-30. Download
  45. Pandamooz, S., Salehi, M.S., Nabiuni, M., Dargahi, L., Valproic acid preserves motoneurons following contusion in organotypic spinalcord slice culture. The Journal of Spinal Cord Medicine 2017, 40(1): 100-106. Download
  46. Mohammad-Rezazadeh, F., Jafarzadeh Shirazi, M.R., Zamiri, M.J., Salehi, M.S., Namavar, M.R., Akhlaghi, A., Tamadon, A., Tsutsui, K., Seasonal changes in hypothalamic gonadotropin inhibitory hormone expression in the paraventricular nucleus of chukar partridge (Alectoris chukar). Animal Reproduction 2017, 14(2): 452-458. Download
  47. Pandamooz, S., Salehi, M.S., Nabiuni, M., Dargahi, L., Pourghasem, M., Evaluation of epidermal neural crest stem cells in organotypic spinal cord slice culture platform. Folia Biologica 2016, 62: 263-267. Download
  48. Salehi, M.S., Mirzaii-Dizgah, I., Vasaghi-Gharamaleki, B., Zamiri, M.J., Effect of hindlimb unloading on stereological parameters of the motor cortex and hippocampus in male rats. Neuroreport 2016, 27(16): 1202-1205. Download
  49. Salehi, M.S., Tamadon, A., Jafarzadeh Shirazi, M.R., Namavar, M.R., Zamiri, M.J., The role of arginine-phenylalanine-amide-related peptides in mammalian reproduction. International Journal of Fertility & Sterility 2015, 9(3): 268-276. Download
  50. Jafarzadeh Shirazi, M.R., Zamiri, M.J., Salehi, M.S., Moradi, S., Tamadon, A., Namavar, M.R., Akhlaghi, A., Tsutsui, K., Caraty, A., Differential expression of RFamide-related peptide, a mammalian gonadotrophin-inhibitory hormone orthologue, and kisspeptin in the hypothalamus of Abadeh ecotype does during breeding and anoestrous seasons. Journal of Neuroendocrinology 2014, 26(3): 186-194. Download
  51. Zandi, M.R., Jafarzadeh Shirazi, M.R., Tamadon, A., Akhlaghi, A., Salehi, M.S., Niazi, A., Moghadam, A., Hypothalamic expression of melanocortin-4 receptor and agouti-related peptide mRNAs during the estrous cycle of rats. International Journal of Molecular and Cellular Medicine 2014, 3(3): 183-189. Download
  52. Arjmand, M., Mirzaei, A., Jafarzadeh Shirazi, M.R., Tamadon, A., Salehi, M.S., Saeb, M., Namavar, M.R., Zandi, M.R., Shahheidari, H., Moradi, M., Clarke, I.J., Luteal activity of Abadeh ecotype does in summer and winter and the effect of a single dose of kisspeptin-10 injection on luteinizing hormone secretion in the anestrus does. Veterinary Research Forum 2014, 5(4): 247-254. Download
  53. Salehi, M.S., Tamadon, A., Vahedi, M., Rahmanifar, F., Jafarzadeh Shirazi, M.R., Aghazi, M., Change in sex ratio among newborn rats in response to potassium supplements (In Persian with English abstract). Journal of Veterinary Research. 2014, 69(3): 227-230. Download
  54. Salehi, M.S., Jafarzadeh Shirazi, M.R., Zamiri, M.J., Pazhoohi, F., Namavar, M.R., Niazi, A., Ramezani, A., Tanideh, N., Tamadon, A., Zarei, A., Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats. International Journal of Fertility & Sterility 2013, 6(4): 304-309. Download
  55. Pazhoohi, F., Salehi, M.S., Effect of gonadotropin inhibitory hormone (GnIH) secretion on post-ejaculatory refractory period. Hypothesis 2013, 11(1): e2. Dwonload
  56. Jafarzadeh Shirazi, M.R., Pazhoohi, F., Zamiri, M.J., Salehi, M.S., Namavar, M.R., Tanideh, N., Tamadon, A., Zarei, A., Tsutsui, K., Expression of RFamide-related peptide in the dorsomedial nucleus of hypothalamus during the estrous cycle of rats (In Persian with English Abstract). Physiology and Pharmacology, 2013, 17(1): 72-79. Download
  57. Salehi, M.S., Namavar, M.R., Jafarzadeh Shirazi, M.R., Rahmanifar, F., Tamadon, A., A simple method for isolation of the anteroventral periventricular and arcuate nuclei of the rat hypothalamus. International Journal of Experimental and Clinical Anatomy 2012-2013, 6-7: 48-51. Download